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KMID : 0361620080430050551
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Journal of the Korean Orthopaedic Association
2008 Volume.43 No. 5 p.551 ~ p.559
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Neuroprotection for Acute Spinal Cord Injury - Comparison of Simvastatin and Atorvastatin -
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Lee Jun-Young
Sohn Hong-Moon
You Jae-Won
Yang Kyung-Ho
Nam Gi-Young
Kwon Brina K
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Abstract
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Purpose: To evaluate the neuroprotective effect of statins after a spinal cord injury.
Materials and Methods: Twenty four Sprague Dawley rats had a spinal cord injury at T9/10 using an Ohio State University (OSU) impactor. The animals were randomized to receive either simvastatin, atorvastatin, or saline with oral gavage everyday for 7 days. A behavioral outcome assessment was performed on days 2, 4 and 7, and then every week using the Basso, Bresnahan, and Beattie (BBB) score and subscore. The animals also underwent sensory threshold testing using a von Frey monofilament device. The animals were sacrificed at the end of 6 weeks and a spinal cord specimen was harvested. Histology and immunohistochemistry were performed to measure the areas of white and gray matter, and the sparing of oligodenrocytes.
Results: For the animals treated with simvastatin, atorvastatin and saline, the mean BBB scores at 6 weeks post-injury was 13.2±0.1, 11.8±0.5, and 11.3±0.2 and the BBB subscores were 9.2±1.1, 4.8±1.8 and 4.4±1.4 respectively (p＜0.05). The areas of white matter at the lesion epicenter were 0.78±0.05, 0.5±0.18 and 0.41±0.03 mm2 in the simvastatin, atorvastatin and saline groups respectively, and the number of spared oligodendrocytes was significantly higher in the simvastatin treated animals (p＜0.05).
Conclusion: The simvastatin treatment improved the behavior and histological sparing of the spinal cord after an acute spinal cord injury in rats.
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KEYWORD
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Acute spinal cord injury, Neuroprotection, Simvastatin, Atorvastatin
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